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15-501 refers to the length of highway where US 15 and US 501 run concurrently.

  • Northern terminus: 501 exits I-85 north of Durham, NC to follow North Duke Street, while 15 continues concurrently with I-85 North.
  • Southern terminus: 15 and 501 merge onto US 401 just north of Laurinberg, NC; 501 then merges onto I-74 (exit 183) East while 15 continues South on 401.

It also refers to a number of business spurs, usually qualified with "business" or "Boulevard"; the main road is technically a "bypass", but when there are both business and bypass routes, "15-501" by itself is generally understood to mean the bypass.

The entirety of 15-501 is within North Carolina.